Cardiovascular Risk, Nutrition and Aging

Cardiovascular Risk, Nutrition and Aging

Cardiovascular disease is the leading cause of premature death in industrialized countries, accounting for 30% of all deaths worldwide. This public health problem requires priority attention. It has been observed that lifestyle, in particular following a healthy dietary pattern such as the Mediterranean diet, can play a crucial role in the prevention of this disease, as well as in the management of associated risk factors such as diabetes, obesity, hypertension and dyslipidemia, among others. From clinical studies, randomized, large sample size, long-term intervention studies, we obtain results with the maximum objectivity. Therefore, the aim of our group is to find ways to prevent the onset of cardiovascular disease and associated risk factors such as diabetes, dyslipidemia, hypertension or obesity.

Ramon Estruch
Investigador principal
Ramon Estruch

Professor Ramon Estruch is a senior consultant at the Internal Medicine Service of Hospital Clínic and principal investigator of the Cardiovascular Risk, Nutrition and Healthy Wrapping group at the FUNDACIÓ DE RECERCA CLÍNIC BARCELONA-INSTITUT D’INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER. Prof. Estruch, has an h-index of 93, 656 articles, 5 books and 52 book chapters, where 150 of them have been published in journals and magazines of the first quartile and decile as NEJM, The Lancet, The Lancet Endocrinology, JAMA, Annals of Internal Medicine, Circulation and JACC. He has been an investigator in more than 80 competitive projects and has achieved Highly Cited Researcher recognition for Clarivate Analytics from 2018 to 2022. Prof. Estruch has been the leader of several multicenter (and multi-country) randomized trials, such as the PREDIMED study, the PREDIMED-Plus trial, the randomized intervention trial of the SI¡ with MD program, the IMPACT study and the MEDCARS cohort study.

He has received several awards that highlight his scientific career as:

Award for Scientific Trajectory in Food, Nutrition and Health “Dr. Carles Martí Henneberg” 2021.
Josep Trueta Award to the scientific career of the Academy of Medical Sciences of Catalonia and the Balearic Islands 2020.
DAVID KRITCHEVSKY LIFESTYLE Lecture Award, AHA/ASA,PHOENIX, USA, 2016
Award for Excellence in Research of the International Nut and Dried Fruit Foundation. 2018

To highlight her direct or indirect participation in the following clinical guidelines:

Dietary Guidelines for North Americans 2015-2020. 8th ed. USDA: American Heart Association (AHA).
American Stroke Association (ASA)
European Society of Cardiology (ESC)
European Society of Hypertension (ESH)

https://orcid.org/0000-0003-1260-4445
Equip
Línies de recerca
  • Efectes protectors de la dieta mediterrània

    Efectes protectors de la dieta mediterrània en la prevenció cardiovascular i cerebrovascular (malalties cròniques, malalties neurodegeneratives i càncer).

  • Efectes protectors de l'alcohol (cervesa o vi)

    Efectes protectors de l’alcohol, begudes fermentades com la cervesa o el vi, el consum sobre la salut.

  • Efectes d'altres components de la dieta sobre la salut

    Efectes d’altres components de la dieta (oli d’oliva, fruits secs, cacau, àcids grassos, tomàquets, etc.) en la prevenció cardiovascular i cerebrovascular (malalties cròniques, malalties neurodegeneratives i càncer).

  • Valoració dels factors de risc cardiovascular en prevenció primària

    Valoració dels factors de risc cardiovascular en prevenció primària, especialment la pressió arterial.

  • Avaluació del gruix íntima-mitjana (IMT) de l'artèria caròtida i placa d'ecografia

    Avaluació del gruix íntima-mitjana (IMT) de l’artèria caròtida i de la placa d’ecografia. Associacions amb factors de risc convencionals i emergents i biomarcadors de la dieta. Influència de la dieta en la vulnerabilitat de les plaques d’ateroma carotidi avaluada mitjançant una RMN.

  • Envelliment

    Els efectes dels components bioactius de la dieta sobre l’escurçament de la longitud dels telòmers leucòcits.

  • Trombosi

    Efectes de la dieta mediterrània sobre els nivells de plaquetes i el seu paper en el risc cardiovascular, així com els mecanismes bioquímics de la trombosi.

Domínguez-López I, Casas R, Chiva-Blanch G, Martínez-González MÁ, Fitó M, Ros E, Lamuela-Raventós RM, Estruch R.

Serum vitamin B12 concentration is associated with improved memory in older individuals with higher adherence to the Mediterranean diet

Clin Nutr. 2023 Dec;42(12):2562-2568.; DOI: https://10.1016/j.clnu.2023.10.025

Konieczna J, Ruiz-Canela M, Galmes-Panades AM, Abete I, Babio N, Fiol M, Martín-Sánchez V, Estruch R, Vidal J, Buil-Cosiales P, García-Gavilán JF, Moñino M, Marcos-Delgado A, Casas R, Olbeyra R, Fitó M, Hu FB, Martínez-Gonzalez MÁ, Martínez JA, Romaguera D, Salas-Salvadó J

An Energy-Reduced Mediterranean Diet, Physical Activity, and Body Composition: An Interim Subgroup Analysis of the PREDIMED-Plus Randomized Clinical Trial

JAMA Netw Open. 2023 Oct 2;6(10):e2337994.; DOI: https://10.1001/jamanetworkopen.2023.37994

Estruch R, Lamuela-Raventós RM.

Cardiovascular benefits of fermented foods and beverages: still up for debate

Nat Rev Cardiol. 2023 Dec;20(12):789-790. ; DOI: https://10.1038/s41569-023-00938-3

Castro-Barquero S, Casas R, Rimm EB, Tresserra-Rimbau A, Romaguera D, Martínez JA, Salas-Salvadó J, Martínez-González MA, Vidal J, Ruiz-Canela M, Konieczna J, Sacanella E, García-Gavilán JF, Fitó M, García-Arellano A, Estruch R.

Loss of Visceral Fat is Associated with a Reduction in Inflammatory Status in Patients with Metabolic Syndrome

Loss of Visceral Fat is Associated with a Reduction in Inflammatory Status in Patients with Metabolic Syndrome; DOI: https://10.1002/mnfr.202200264

Casas R, Castro-Barquero S, Crovetto F, Larroya M, Ruiz-León AM, Segalés L, Nakaki A, Youssef L, Benitez L, Casanovas-Garriga F, Vieta E, Crispi F, Gratacós E, Estruch R.

Maternal Dietary Inflammatory Index during Pregnancy Is Associated with Perinatal Outcomes: Results from the IMPACT BCN Trial

Nutrients. 2022 May 29;14(11):2284; DOI: https://10.3390/nu14112284

Crovetto F, Crispi F, Casas R, Martín-Asuero A, Borràs R, Vieta E, Estruch R, Gratacós E

IMPACT BCN Trial Investigators. Effects of Mediterranean Diet or Mindfulness-Based Stress Reduction on Prevention of Small-for-Gestational Age Birth Weights in Newborns Born to At-Risk Pregnant Individuals: The IMPACT BCN Randomized Clinical Trial.

JAMA. 2021 Dec 7;326(21):2150-2160. ; DOI: https://10.1001/jama.2021.20178

Estruch R, Martínez-González MA, Corella D, Salas-Salvadó J, Fitó M, Chiva-Blanch G, Fiol M, Gómez-Gracia E, Arós F, Lapetra J, Serra-Majem L, Pintó X, Buil-Cosiales P, Sorlí JV, Muñoz MA, Basora-Gallisá J, Lamuela-Raventós RM, Serra-Mir M, Ros E; PREDIMED Study Investigators.

Effect of a high-fat Mediterranean diet on bodyweight and waist circumference: a prespecified secondary outcomes analysis of the PREDIMED randomised controlled trial.

Lancet Diabetes Endocrinol. 2019 May;7(5):e6-e17. ; DOI: https://10.1016/S2213-8587(19)30074-9

Estruch R, Ros E, Salas-Salvadó J, Covas MI, Corella D, Arós F, Gómez-Gracia E, Ruiz-Gutiérrez V, Fiol M, Lapetra J, Lamuela-Raventos RM, Serra-Majem L, Pintó X, Basora J, Muñoz MA, Sorlí JV, Martínez JA, Fitó M, Gea A, Hernán MA, Martínez-González MA; PREDIMED Study Investigators

Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts.

N Engl J Med. 2018 Jun 21;378(25):e34.; DOI: https://10.1056/NEJMoa1800389

; DOI:

Efecto de una intervención con dieta mediterránea hipocalórica, ayuno intermitente y senolíticos naturales en los marcadores de senescencia celular.

Ramon EStruch i Emilio Sacanella

2024-2026

Entitat finançadora: Instituto de Salud Carlos III (ISCIII)

Convocatòria: FIS23

Data d’inici: 01/01/2024

Data de finalització: 31/12/2026

Quantia de la subvenció: 299.375,00

Asociación entre biomarcadores de consumo de vino, acido tartárico y metabolitos del resveratrol, con parámetros de inflamación y oxidación.

Maria Pérez i Rosa Casas

2023

Entitat finançadora: Fundación para la investigación del vino y nutrición (FIVIN).

Convocatòria: 2022

Data d’inici: 01/01/2023

Data de finalització: 01/01/2024

Quantia de la subvenció: 33.500 €

Peanut consumption on cognitive performance, weight management, and inflammation in young adolescents (PEANUTY).

Anna Tresserra i Rosa M. Casas

2023

Entitat finançadora: The Peanut Institute

Convocatòria: 2022

Data d’inici: 01/09/2023

Data de finalització: 01/09/2024

Quantia de la subvenció: 235.000 €

Deciphering the interplay between mediterranean diet, inflammation, vascular homeostasis, and childhood obesity

Luis A. Moreno; Rosa M. Casas; Gemma Chiva-Blanch; Emily Laveriano Santos

2023

Entitat finançadora: CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN)

Convocatòria: 2023

Data d’inici: 22/05/2023

Data de finalització: 22/05/2024

Quantia de la subvenció: 50.000 €

Effect of an intensive weight loss intervention with hypocaloric Mediterranean diet, physical activity and behavioural treatment on cardiovascular primary prevention: PREDIMED-Plus trial.

Ramon Estruch

2020

Nom de l’IP: Ramon Estruch

Agència finançadora: Instituto de Salud Carlos III (ISCIII)

Convocatòria: Convocatòria 2019

Data d’inici: 01/01/2020

Data de finalització: 31/12/2022

Quantia de la subvenció: 98.917,50 €.

Food phytochemicals are important for cardiometabolic health

Ramon Estruch

2020

Agència finançadora: Instituto de Salud Carlos III (ISCIII)

Convocatòria: Convocatòria 2020

Data d’inici: 01/01/2020

Data de finalització: 31/12/2022

Quantia de la subvenció: 99.000 €

Muscle mass in patients with colorectal or lung cancer when receiving a n-3 PUFA and leucine enriched high protein and high energy oral nutritional supplement during anti-cancer treatment.

Ramon Estruch

2023

Entitat finançadora: Danone Nutricia Research

Convocatòria: 2023

Data d’inici: 01/01/2024

Data de finalització: 31/12/2026

 

Improving Mothers for a better PrenAtal Care Trial (IMPACT)

Ramon Estruch, Fàtima Crispi, Eduard Gratacòs

2017

Agència finançadora: La Caixa

Convocatòria: Convocatòria 2017

Data d’inici: 1/01/2017

Data de finalització: 31/12/2022

Quantia de la subvenció: 122.738,45 €

Clinical efficacy of a low-histamine diet and/or DAO enzyme supplementation in the treatment of symptoms associated with histamine intolerance due to DAO deficiency: a double-blind, randomized, placebo-controlled interventional clinical trial.

M.Carmen Vidal Carou/Ramon Estruch

2021

Entitat finançadora: DR.Healthcare S.L

Data d’inici: 06/2021

Data de finalització: 05/2024

Quantia de la subvenció: 402.626,83 €

DR.Healthcare S.L

Vegenat Healthcare

Laboratorios Grand Fontaine

Effects de dietary polyphenol intake on metabòlic syndrome, body composition and obesity-related inflammation

Defensa de la tesi: 30/05/2022. Excellent Cum Laude i menció internacional. Actualment, la Dra. Sara Castro és col·laboradora externa del grup.

2022

Efectos de la ingesta moderada de vinos andaluces de crianza biológica sobre la función endotelial

Defensa de la tesi: 18/09/2019. Excellent Cum Laude.

2019

Efecto de la Dieta Mediterránea sobre los patrones de tratamiento farmacológico en adultos con alto riesgo cardiovascular

Defensa de la tesi: 16/12/2022. Excellent Cum Laude.

2022