Toxicology Research Group (GRET)

Toxicology Research Group (GRET)

The toxicology research group is focused on advancing our understanding of the toxic effects of pollutants and chemicals on human health through various areas of interest. We specialise in assessing the toxicity and risk associated with exposure to xenobiotics during critical stages of development. In addition, we carry out studies to identify the molecular mechanisms underlying the toxic effects of chemical substances on neuronal development. We are also investigating the use of in vitro and in vivo models for the detection and assessment of developmental toxicity.

GRET is a consolidated AGAUR research group since 2005, renewed in each competitive call until now (2021 SGR 01579). GRET develops several research projects with public and private funds, as well as contractual services for companies in different fields related to toxicity assessment and risk assessme

Elisabet Teixidó Condomines
Investigador principal
Elisabet Teixidó Condomines

Lecturer at the Department of Pharmacology, Toxicology and Therapeutic Chemistry of the Faculty of Pharmacy and Food Sciences at the University of Barcelona since 2020. She has a degree in Pharmacy and a PhD in Biomedicine from the UB. After finishing her PhD, she joined the ecotoxicology group led by Dr. Stefan Scholz, at the Helmholtz Center for Environmental Research where she had a 4-year postdoctoral contract. During the postdoctoral period, she participated in the project “Development of a strategy to reduce animal testing for teratogenicity testing by combining mammalian testing with the zebrafish embryo test” funded by the German Ministry of Education (BMBF). She is currently leading the Toxicology Research Group (GRET).

She has published more than 25 articles in indexed journals, with an h-index of 13 and a total number of citations of 482. Many of these articles have been in the top quartile of journals in recent years, indicating the growing quality of her research and her upward trajectory. She is first author on several of these articles and has contributed three book chapters. In recent years, she has obtained two projects funded by competitive calls as a member of the research team, being responsible for the toxicological part of these projects.

All these merits have earned her an award from the 2013-1018 research programme. Dr. Teixidó’s experience is mainly focused on the field of alternative methods for the assessment of developmental toxicity and the assessment of the genotoxicity of various chemical products.

She is a lecturer in Toxicology and Food Safety on the Bachelor’s Degree in Pharmacy, Food Science and Technology. She teaches on the Master’s Degree in Food Safety, the Master’s Degree in Integrated Water Science and Management and the Master’s Degree in Research, Development and Control of Medicines.

https://orcid.org/0000-0002-0146-876X
Equip
Línies de recerca
  • Avaluació de la toxicitat sobre el desenvolupament amb models experimentals alternatius.

    Se centra en l’estudi dels efectes tòxics de diverses substàncies químiques sobre el desenvolupament utilitzant models alternatius. Actualment utilitzem el model de peix zebra i el cultiu de neuroesferes. El model de peix zebra permet observar de manera ràpida i directa les anomalies de desenvolupament a causa de la seva transparència embrionària i similitud genètica amb els humans. A més, les tècniques de manipulació genètica són ben establertes en el peix zebra, permetent estudis detallats sobre els mecanismes de la toxicitat, i es poden avaluar múltiples tipus de toxicitats, incloent la neurotoxicitat, la cardiotoxicitat i la teratogenicitat, en un sol sistema.

    Les neuroesferes són cultius tridimensionals de cèl·lules progenitores neurals que es diferencien en diversos tipus de cèl·lules del sistema nerviós, oferint un model rellevant per a l’estudi de la toxicitat neuronal. Les neuroesferes proporcionen un entorn tridimensional que imita millor l’arquitectura del cervell en desenvolupament en comparació amb els cultius bidimensionals; permeten l’estudi de la diferenciació cel·lular, la proliferació i la migració de neurones, així com la formació de xarxes neuronals; faciliten el control precís de les condicions experimentals i l’accés directe a les cèl·lules per a l’anàlisi molecular i funcional.

  • Avaluació del risc per la salut per exposició a substancies toxiques (ambiental, alimentari, laboral, domèstic).

Wilhelmi, P., Haake, V., Zickgraf, F. M., Giri, V., Ternes, P., Driemert, P., Nöth, J., Scholz, S., Barenys, M., Flick, B., Birk, B., Kamp, H., Landsiedel, R., & Funk-Weyer, D.

Molecular signatures of angiogenesis inhibitors: a single-embryo untargeted metabolomics approach in zebrafish.

Archives of toxicology, 2024, 98(3): 943–956. ; DOI: https://doi.org/10.1007/s00204-023-03655-5

Romero, N.G.; Gutierrez, G.; Teixidó, E.; Li, L.; Klose, J.; Ping Chung, L.; Cañigueral, S.; Fritsche, E.; Barenys, M.

Developmental neurotoxicity evaluation of three Chinese herbal medicines in zebrafish larvae by means of two behavioral assays: Touch-evoked response and light/dark transition

Reproductive Toxicology, 2023; DOI: https://doi.org/10.1016/j.reprotox.2023.108469

Teixidó, E.; Riera-Colomer, C.; Raldúa, D.; Pubill, D.; Escubedo, E.; Barenys, M.; López-Arnau, R.

First-Generation Synthetic Cathinones Produce Arrhythmia in Zebrafish Eleutheroembryos: A New Approach Methodology for New Psychoactive Substances Cardiotoxicity Evaluation

International Journal of Molecular Sciences, 2023, 24(18): 13869; DOI: https://doi.org/10.3390/ijms241813869

Wilhelmi, P., Giri, V., Zickgraf, F. M., Haake, V., Henkes, S., Driemert, P., Michaelis, P., Busch, W., Scholz, S., Flick, B., Barenys, M., Birk, B., Kamp, H., Landsiedel, R., & Funk-Weyer, D.

A metabolomics approach to reveal the mechanism of developmental toxicity in zebrafish embryos exposed to 6-propyl-2-thiouracil.

Chemico-biological interactions, 2023 382: 110565. ; DOI: https://doi.org/10.1016/j.cbi.2023.110565

Kühne, B. A., Gutierrez-Vázquez, L., Sánchez Lamelas, E., Guardia-Escote, L., Pla, L., Loreiro, C., Gratacós, E., Barenys, M., & Illa, M.

Lactoferrin/sialic acid prevents adverse effects of intrauterine growth restriction on neurite length: investigations in an in vitro rabbit neurosphere model

Frontiers in cellular neuroscience, 2023, 17:1116405.; DOI: https://doi.org/10.3389/fncel.2023.1116405

Kühne, B. A., Vázquez-Aristizabal, P., Fuentes-Amell, M., Pla, L., Loreiro, C., Gómez-Catalán, J., Gratacós, E., Illa, M., & Barenys, M.

Docosahexaenoic Acid and Melatonin Prevent Impaired Oligodendrogenesis Induced by Intrauterine Growth Restriction (IUGR).

Biomedicines, 2022, 10(5): 1205. ; DOI: https://doi.org/10.3390/biomedicines10051205

Britta Anna Kühne; Elisabet Teixidó; Miren Ettcheto; Teresa Puig; Marta Planas; Lidia Feliu; Laura Pla; Victoria Campuzano; Eduard Gratacós; Ellen Fritsche; Miriam Illa; Marta Barenys.

Application of the adverse outcome pathway to identify molecular changes in prenatal brain programming induced by IUGR: Discoveries after EGCG exposure

Food and Chemical Toxicology, 2022, 170: 113506.; DOI: https://doi.org/10.1016/j.fct.2022.113506

Pla, L., Kühne, B. A., Guardia-Escote, L., Vázquez-Aristizabal, P., Loreiro, C., Flick, B., Gratacós, E., Barenys, M., & Illa, M.

Protocols for the Evaluation of Neurodevelopmental Alterations in Rabbit Models In Vitro and In Vivo.

Frontiers in toxicology, 2022, 4: 918520. ; DOI: https://doi.org/10.3389/ftox.2022.918520

Teixidó, E., Kieβling, T. R., Klüver, N., & Scholz, S.

Grouping of chemicals into mode of action classes by automated effect pattern analysis using the zebrafish embryo toxicity test.

Archives of toxicology, 2022, 96(5): 1353–1369. ; DOI: https://doi.org/10.1007/s00204-022-03253-x

Barenys, M., Álvarez, S., Santamaria, A., Teixidó, E., & Gómez-Catalán, J.

Developmental exposure to MDMA (ecstasy) in zebrafish embryos reproduces the neurotoxicity adverse outcome 'lower motor activity' described in humans.

Neurotoxicology, 2022, 88: 116–123. ; DOI: https://doi.org/10.1016/j.neuro.2021.11.001

Barenys M., Illa-Armengol M., Hofrichter M., Loreiro C., Pla-Codina L., Klose J., Kühne B.A., Gómez-Catalán J., Braun J.M., Fàtima Crispi Brillas, Gratacós E. and Fritsche E.

Rabbit neurospheres as a novel in vitro tool for studying neurodevelopmental effects induced by intrauterine growth restriction

Stem Cells Translational Medicine 2021. 10(2): 209-221. ; DOI: https://doi.org/10.1002/sctm.20-0223

Arteaga, C., Boix, N., Teixido, E., Marizande, F., Cadena, S., & Bustillos, A.

The Zebrafish Embryo as a Model to Test Protective Effects of Food Antioxidant Compounds

Molecules (Basel, Switzerland), 2021, 26(19): 5786.; DOI: https://doi.org/10.3390/molecules26195786

Guzman, L., Besa, G., Linares, D., González. L., Pont, C., Bartolini, M., Haigis, A.C., Legradi, J., Muñoz-Torrero, D., Gómez-Catalán, J., Barenys, M.

Evaluation of the effects of acetylcholinesterase inhibitors in the zebrafish touch-evoked response: quantitative vs. qualitative assessment.

Environmental Sciences Europe, 2020, 32:145; DOI: https://doi.org/10.1186/s12302-020-00421-7

Boix, N., Teixido, E., Pique, E., Llobet, J. M., & Gomez-Catalan, J.

Modulation and Protection Effects of Antioxidant Compounds against Oxidant Induced Developmental Toxicity in Zebrafish.

Antioxidants (Basel, Switzerland), 2020, 9(8): 721. ; DOI: https://doi.org/10.3390/antiox9080721

Teixidó, E., Barenys, M., Piqué, E., Llobet, J. M., & Gómez-Catalán, J.

Cardiovascular Effects of PCB 126 (3,3',4,4',5-Pentachlorobiphenyl) in Zebrafish Embryos and Impact of Co-Exposure to Redox Modulating Chemicals.

International journal of molecular sciences, 2019, 20(5): 1065. ; DOI: https://doi.org/10.3390/ijms20051065

Kühne, B. A., Puig, T., Ruiz-Martínez, S., Crous-Masó, J., Planas, M., Feliu, L., Cano, A., García, M. L., Fritsche, E., Llobet, J. M., Gómez-Catalán, J., & Barenys, M.

Comparison of migration disturbance potency of epigallocatechin gallate (EGCG) synthetic analogs and EGCG PEGylated PLGA nanoparticles in rat neurospheres.

Food and chemical toxicology, 2019, 123: 195–204. ; DOI: https://doi.org/10.1016/j.fct.2018.10.055

Barenys, M., Reverte, I., Masjosthusmann, S., Gómez-Catalán, J., & Fritsche, E.

Developmental neurotoxicity of MDMA. A systematic literature review summarized in a putative adverse outcome pathway.

Neurotoxicology, 2020, 78: 209–241. ; DOI: https://doi.org/10.1016/j.neuro.2019.12.007

Cano, A., Ettcheto, M., Chang, J. H., Barroso, E., Espina, M., Kühne, B. A., Barenys, M., Auladell, C., Folch, J., Souto, E. B., Camins, A., Turowski, P., & García, M. L.

Dual-drug loaded nanoparticles of Epigallocatechin-3-gallate (EGCG)/Ascorbic acid enhance therapeutic efficacy of EGCG in a APPswe/PS1dE9 Alzheimer's disease mice model.

Journal of controlled release : official journal of the Controlled Release Society, 2019, 301: 62–75. ; DOI: https://doi.org/10.1016/j.jconrel.2019.03.010

Barenys, M., Molins, A., Amorós-Galicia, L., Flick, B., & Gómez-Catalán, J.

Implementation of a functional endpoint to the zebrafish embryotoxicity test to evaluate craniofacial abnormalities.

Toxicology in vitro, 2019, 61: 104638. ; DOI: https://doi.org/10.1016/j.tiv.2019.104638

Desarrollo de productos de tomate sostenibles para mejorar el eje microbiota-intestino-cerebro: de la granja a la mesa y la salud

Rosa M. Lamuela Raventos / Anna Vallverdu Queralt

2021-2024

Ref: PID2020-114022RB-I00, Ministerio de Ciencia e Innovación

Modelos in vitro para predecir fotosensibilización de contacto: estrategias basadas en los mecanismos celulares implicados

Montserrat Mitjans

2021-2025

Ref.: PID2020-113186RB-I00

Evaluación in vitro e in vivo de terapias neuroprotectoras en un modelo animal de restricción de crecimiento intraútero.

Miriam Illa

2019-2021

Ministerio de Economia y Competitividad.

Noves polimixines per al tractament d'infeccions causades per bacteris multiresistents.

Fransesc Rabanal

2019-2021

Fundació La Marató de TV3

Efecto de los polifenoles de la dieta en la sensibilidad a la insulina, marcadores de inflamacion y en la incidencia de la diabetes tipo II.

Rosa M Lamuela

2017-2020

Programa estatal de investigación, desarrollo e innovación orientada a los retos de la sociedad. Ministerio de economía y competitividad.

Contractes per a l'elaboració, redacció i defensa d'informes d'expert en temes de seguretat i registres

Diferents empreses

Developmental toxicity screening in the zebrafish embryo - a metablomics approach

Directors: Marta Barenys, Burkhard Flick and Franziska Zickgraf

2024

Evaluation of neurodevelopmental protective therapies in vivo and in vitro in models of intrauterine growth restriction

Directores: Marta Barenys i Miriam Illa

http://hdl.handle.net/2445/191325

2022

Evaluación de la actividad anti-inflamatoria mediante modelos experimentales basados en el embrión de pez cebra. Aplicación a compuestos presentes en la Alimentación

Director: Jesús Gómez-Catalán

http://hdl.handle.net/2445/118385

2017

Un model d'estrès oxidatiu en embrió de peix zebra. Aplicació per a l'avaluació de l'activitat protectora de substàncies antioxidants.

Director: Jesús Gómez Catalán, Esther Piqué Benages i Joan M Llobet Mallafré

http://hdl.handle.net/2445/69124

2015