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Adaptive Physiology: Exercise, Hypoxia and Health (FEHS-Lab)

Adaptive Physiology: Exercise, Hypoxia and Health (FEHS-Lab)
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Our main objective is to study the functional effect of bioactive food components in combination with physical exercise and intermittent hypoxia for the prevention of inflammatory and metabolic alterations, the improvement of physical capacity and fatigue resistance as well as for the recovery of musculoskeletal injuries.

The FEHS-Lab, research group from the Faculty of Biology of the UB, has been focused on the functional study of bioactive food components (microalgae, fish oil ω3, root polyphenols, fiber…) for the last 20 years. Our translational research focuses on the bioactive effect of nutritional products in combination with physical exercise and intermittent hypoxia and the potential favorable effect on metabolic diseases, such as Diabetes Mellitus type 2.

Ginés Viscor Carrasco
Investigador principal
Ginés Viscor Carrasco

Professor of the Department of Cell Biology, Physiology and Immunology of the Faculty of Biology of the University of Barcelona and leader of the Adaptive Physiology Group: Exercise, Hypoxia and Health (2021 SGR 01110). Scientific leader of the Hypobaria and Biomedical Physiology Service of the Bellvitge Campus of the UB. Current research focuses on the interaction between functional food and adaptive responses, at central and peripheral levels, to exercise and hypoxic conditions, especially intermittent exposure to hypobaric hypoxia.

Technology transfer activities in the biomedical and sports medicine fields. General coordinator of the ALTMEDFIS Network (Iberoamerican Network of High Altitude Medicine and Physiology) of the Iberoamerican Program of Science and Technology for Development) during the period 2013-2016. Coordinator of the HYPOXSPORT Network endorsed by the Consejo Superior de Deportes (2019-2022).

https://orcid.org/0000-0003-4942-2346
Equip
Línies de recerca
  • Physical exercise and bioactive nutritional compounds.
  • Metabolic syndrome and bioactive nutritional compounds

Francisco Moreno, Lucía Méndez, Ana Raner, Bernat Miralles-Pérez, Marta Romeu, Sara Ramos-Romero, Josep Lluís Torres, Isabel Medina

Dietary marine oils selectively decrease obesogenic diet-derived carbonylation in proteins involved in atp homeostasis and glutamate metabolism in the rat cerebellum

Antioxidants, 2024, 13: 103 ; DOI: https://doi.org/10.3390/antiox13010103

Karenia Lorenzo, Garoa Santocildes, Joan Ramón Torrelas, Teresa Pagès, Ginés Viscor, Josep L. Torres, Sara Ramos-Romero

Bioactivity of macronutrients from Chlorella in physical exercise and sports

Nutrients, 2023, 15(9): 2168; DOI: https://doi.org/10.3390/nu15092168

Sara Ramos-Romero, Julia Ponomarenko, Susana Amézqueta, Mercè Hereu, Bernat Miralles-Pérez, Marta Romeu, Lucía Méndez, Isabel Medina, Josep L. Torres

Fiber-like action of d-Fagomine on the gut microbiota and body weight of healthy rats

Nutrients, 2022, 14: 4656.; DOI: https://doi.org/10.3390/nu14214656

Sara Ramos-Romero, Joan Ramon Torrella, Teresa Pagès, Ginés Viscor, Josep L. Torres

Edible microalgae and their bioactive compounds in the prevention and treatment of metabolic alterations

Nutrients, 2021, 13: 1-16; DOI: https://doi.org/10.3390/nu13020563

Sara Ramos-Romero, Asier Léniz, Daniel Martínez-Maqueda, Susana Amézqueta, Alfredo Fernández-Quintela, Mercè Hereu, Josep Luís Torres, María Puy Portillo, Jara Pérez-Jiménez

Inter-individual variability in insulin response after grape pomace supplementation in subjects at high cardiometabolic risk: role of microbiota and miRNA

Molecular Nutrition and Food Research, 2021, 65: e2000113; DOI: https://doi.org/10.1002/mnfr.202000113

Mercè Hereu, Sara Ramos-Romero, Cristina Busquets, Lidia Atienza, Susana Amézqueta, Bernat Miralles-Pérez, Maria Rosa Nogués, Lucía Méndez, Isabel Medina, Josep Lluís Torres

Effects of combined d-Fagomine and omega-3 PUFAs on gut microbiota subpopulations and diabetes risk factors in rats fed a high-fat diet

Scientific Reports, 2019, 9: 16628-16628; DOI: https://doi.org/10.1038/s41598-019-52678-5

Sara Ramos-Romero, Mercè Hereu, Lidia Atienza, Fina Casas, Olga Jáuregui, Susana Amézqueta, Gabriel Dasilva, Isabel Medina, Maria Rosa Nogués, Marta Romeu, Josep Lluís Torres

Mechanistically different effects of fat and sugar on insulin resistance, hypertension and gut microbiota in rats

American Journal of Physiology-Endocrinology and Metabolism, 2018, 314: E552-E563; DOI: https://doi.org/10.1152/ajpendo.00323.2017

Edible microalgae as a source for maintaining energy homeostasis. Application to metabolic syndrome induced by diet, physical exercise and hypoxia (mALGAHEALTH).

Josep Lluís Torres / Sara Ramos Romero

2021

REF: PID2020-117009RB-I00

The mALGAHEALTH project aims to investigate the functional effects of the microalgae (Isochrysis galbana and Chlorella vulgaris) against the risk factors of the Metabolic Syndrome (MS, obesity, insulin resistance/hyperglycemia, hyperlipidemia, hypertension) for the prevention of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). The proposal addresses two important social concerns of the growing human population: producing zero waste food in a sustainable way and adopting better nutritional habits. The proposal is based on our previous observations on the role of omega-3 long-chain polyunsaturated fatty acids in the ratio EPA/DHA 1:1 and prebiotic components (saccharides) at different stages and levels during the progression of metabolic disorders. The suggested mixture (ISORELLA) presents the adequate proportion of these two types of molecules to ensure their combined action, while including other minor components (pigments, carotenoids, peptides) that could contribute to this effect with their antioxidant and antihypertensive activities.

To evaluate the possible application of ISORELLA to human consumption, an SM model in rates previously defined by the research team will be used, with moderate or no exercise and hypoxia. The main experimental approaches will be i) assessment of early markers of inflammation, insulin resistance and oxidative stress, ii) obtaining the complete intestinal bacterial profile, iii) assessment of microbial products, and iv) measurement of physiological variables. The techniques used will be: determination of glucose metabolism status (glycemia tests, glucose tolerance); lipid profile by lipidomics; blood pressure; inflammation by histology, lymphocyte profile, and macrophage activation (selected organs); mass sequencing of 16S ribosomal DNA (fecal and cecal samples); determination of microbial products; enzyme activities; genetic transcription by transcriptomics; oxygen consumption; assessment of the status of the neural nerve. Microalgae are a real alternative to traditional field crops as a source of high quality protein with zero waste and high CO2 capture capacity. Moreover, they contain components with functional effects against risk factors for T2DM. ISORELLA has been designed to meet the requirements of a functional food or superfood for the prevention of modern epidemics such as metabolic diseases. The results generated in this proposal could lead to new food ingredients for the promotion of human health and obtained in a sustainable way.

 

https://www.ub.edu/portal/web/dp-bioquimicaifisiologia/autoimmunitat-i-tolerancia