Autoimmunity, Immunonutrition and Tolerance (AIT)

Autoimmunity, Immunonutrition and Tolerance (AIT)

Could the diet or bioactive components of food enhance the defenses? Can diet help to mature the immune system? In case of inflammatory or immune disorders or diseases, can diet help in prevention or treatment? How good is the Mediterranean diet, rich in antioxidants and fiber, or breast milk in these effects? In our research group we try to answer these questions.

Margarida Castell Escuer
Investigador principal
Margarida Castell Escuer

Margarida Castell holds a PhD in Pharmacy and is Professor of Physiology of the Physiology Section of the Department of Biochemistry and Physiology of the Faculty of Pharmacy and Food Sciences. Her research career has focused on the function of the immune system in health and disease. Since the early 2000s, her interest has been focused on the interaction between certain food components and the immune system. Among other things, during her career she has established the role of different compounds on immunity in situations of immaturity (early stages of life), deficiency (strenuous physical exercise) or disease (allergy, acute or chronic inflammation, etc).

https://orcid.org/0000-0001-5408-0593
Equip
Línies de recerca
  • Polyphenols and immune system

    The main focus is to establish the influence of polyphenols, such as those in cocoa and orange, or those present in the Mediterranean diet, on the immune system in different physiological (developmental) and pathological (inflammation, allergy, etc.) states.

  • Modulation of the microbiota and immune system

    It focuses on establishing the influence of diet and microbial modulators (probiotics, prebiotics, synbiotics and postbiotics) on the intestinal microbiota and the immune system in early life stages, in certain pathologies and even in immune programming.

  • Maternal milk and the immune system

    The objective is to identify compounds in breast milk that have a positive effect on the development of the immune system and that may be of interest in the development of infant formulas. It also establishes the changes in milk induced by maternal diet or other external factors.

  • Influence of diet on infectious and metabolic processes.

    The potential of various dietary compounds in the prevention and protection of metabolic (diabetic) or infectious disorders, especially digestive (rotavirus, salmonella), is being investigated.

Saez-Fuertes L, Azagra-Boronat I, Massot-Cladera M, Knipping K, Garssen J, Franch A, Castell M, Perez-Cano FJ, Rodriguez-Lagunas MJ

Effect of Rotavirus Infection and 2 '-Fucosyllactose Administration on Rat Intestinal Gene Expression

Nutrients 2023, 15 (8), art. No. 1996.; DOI: https://doi.org/10.3390/nu15081996

Bäuerl C., Zulaica J., Rusu L., Moreno A.R., Pérez-Cano F.J., Lerin C., Mena-Tudela D., Aguilar-Camprubí L., Parra-Llorca A., Martínez-Costa C., Geller R., Collado M.C.

Assessment of SARS-CoV-2 neutralizing antibody titers in breastmilk from convalescent and vaccinated mothers

iScience 2023, 26(6), art no. 106802; DOI: https://doi.org/10.1016/j.isci.2023.106802

Ruiz-Iglesias P, Massot-Cladera M, Rodríguez-Lagunas MJ, Franch À, Camps-Bossacoma M, Pérez-Cano FJ, Castell M.

Protective Effect of a Cocoa-Enriched Diet on Oxidative Stress Induced by Intensive Acute Exercise in Rats

Antioxidants 2022, 11(4), 753; DOI: https://doi.org/10.3390/antiox11040753

del Amo-Maestro L, Mendes SR, Rodríguez-Banqueri A, Garzon-Flores L, Girbal M, Rodríguez-Lagunas MJ, Guevara T, Franch À, Pérez-Cano FJ, Eckhard U, Gomis-Rüth FX.

Molecular and in vivo studies of a glutamate-class prolyl-endopeptidase for coeliac disease therapy

Nature Communications 2022, 13(1), art. no. 4446; DOI: https://doi.org/10.1038/s41467-022-32215-1

Ruiz-Iglesias P., Estruel-Amades S., Camps-Bossacoma M., Massot-Cladera M., Castell M., Pérez-Cano F.J.

Alterations in the mucosal immune system by a chronic exhausting exercise in Wistar rats

Scientific Reports 2020, 10(1), art. no. 17950; DOI: https://doi.org/10.1038/s41598-020-74837-9

Azagra-Boronat I, Tres A, Massot-Cladera M, Franch À, Castell M, Guardiola F, Pérez-Cano FJ, Rodríguez-Lagunas MJ.

Lactobacillus fermentum CECT5716 supplementation in rats during pregnancy and lactation affects mammary milk composition

Journal of Dairy Science 2020, 103(4), 2982-2992; DOI: https://doi.org/10.3168/jds.2019-17384

4.5. Rio-Aige K, Fernández-Bargalló A, Vegas-Lozano E, Miñarro-Alonso A, Castell M, Selma-Royo M, Martínez-Costa C, Rodríguez-Lagunas MJ, Collado MC, Pérez-Cano FJ

Breast milk immune composition varies during the transition stage of lactation: characterization of immunotypes in the MAMI cohort

Frontiers in Nutrition 2023, 10, 1252815; DOI: https://doi.org/10.3389/fnut.2023.1252815

Grases-Pintó B., Abril-Gil M., Castell M., Pérez-Cano F.J., Franch À.

Enhancement of immune maturation in suckling rats by leptin and adiponectin supplementation

Scientific Reports 2019, 9 (1), art. no. 1786; DOI: https://doi.org/10.1038/s41598-018-38418-1

Prevention in prediabetic patients of infection's morbidity following a high fiber and vegetal protein diet

Maria José Rodríguez-Lagunas

2022-2025

Impacto de una dieta materna rica en fibra y polifenoles sobre el desarrollo inmunitario del lactante y la programación inmunitaria a largo plazo

Francisco J. Pérez Cano

2021-2024

Impacto de la dieta durante la gestación y lactancia en el metaboloma y sistema inmunitario de la madre y su descendència

https://www.nutrimetabolomics.com/es/miembros/tomas-merono

Malen Massot Cladera

2022-2023

Impact of maternal SARS-CoV-2 infection and vaccination on breast milk antibodies, milk bioactive compounds and maternal-child health (MilkCORONA)

https://www.iata.csic.es/es/personal/maria-carmen-collado-amores

Francisco J Pérez Cano

2021-2023

Impacte de la suplementació materna amb oli d’oliva verge extra sobre el desenvolupament del sistema immunitari intestinal del lactant

https://polyphenolresearch.com/professional/anna-vallverdu-queralt/

Maria Jose Rodriguez Lagunas

2021-2022

Partícules víriques pseudoembolcallades a exosomes candidates a noves vacunes per la hepatitis A i E

https://scholar.google.es/citations?user=I2X7V0MAAAAJ&hl=es

Margarida Castell

2019-2022

Dietary lmprovement of breast Milk composition to counteract Early Life Infections (DIM-2-ELI)

https://www.iata.csic.es/es/personal/maria-carmen-collado-amores

Francisco J. Pérez Cano

2019-2022

Nuevas propiedades funcionales del cacao sobre el sistema inmunitario y la microbiota en el ejercicio físico intenso

Margarida Castell

2016-2021

Estudio preclínico del efecto de Staphylococcus sobre el desarrollo del sistema inmunitario neonatal - GESTA HEALTH

Francisco J. Pérez Cano

2019-2020

Actividad antiasmática y antiinflamatoria del cacao (Theobroma cacao L.) como coadyuvante en el tratamiento del asma bronquial: evaluación in vitro e in vivo de compuestos bioactivos de 4 variedades de cacao peruano

https://usil.edu.pe/autoridades-academicas/director-gestion-investigacion

Margarida Castell i Francisco J. Pérez Cano

2018-2020

Biopolies S.L.

Nutricia Research B.V.

Biosearch S.A.

Laboratorios Ordesa S.L.

Cuétara 1951 S.L.U.

Danone Research

Nutritional composition for improving intestinal barrier integrity, preparation of the composition and method of treatment

2018

Gluten degrading protein and its uses

2023

Vaccine composition for the treatment or prevention of hepatitis A Infection

2023

Maternal diet and breast milk: Shaping the newborn immune system to fight early life infections

https://diposit.ub.edu/dspace/handle/2445/204048

2023

Impacte d'una sobrecàrrega bacteriana i vírica sobre el sistema immunitari de rates lactants i paper preventiu d'un postbiòtic en la diarrea induïda per rotavirus

https://diposit.ub.edu/dspace/handle/2445/189614

2022

Intensive exercise and immunity: effect of diets enriched in fibre and/or flavonoids in rats

https://diposit.ub.edu/dspace/handle/2445/191516

2022

Estudio del efecto antiasmático de cacao nativo de Perú en un modelo experimental en rata

https://diposit.ub.edu/dspace/handle/2445/192905

2022

Preclinical evaluation of probiotics and prebiotics as modulators of the immune function in early life

2020

Efecto de los factores bioactivos de leche materna TGF-β2, EGF y FGF21 sobre el desarrollo del sistema inmunitario de ratas nacidas a término y a pretérmino

https://diposit.ub.edu/dspace/handle/2445/148505

2019

Influència de la leptina i l'adiponectina sobre el sistema immunitari de rates lactants nascudes a terme i a preterme

https://diposit.ub.edu/dspace/handle/2445/139218

2019

Efectes immunomoduladors de l'exercici físic intens i extenuant i de l'hesperidina en rates

https://diposit.ub.edu/dspace/handle/2445/139261

2019

Influència d’una dieta rica en cacau sobre el sistema immunitari intestinal de rates sensibilitzades

https://diposit.ub.edu/dspace/handle/2445/113928

2017

New food frequency questionnaire to assess cocoa consumption and its relationship with health in university students

https://diposit.ub.edu/dspace/handle/2445/100716

2016

Acció moduladora de prebiòtics i probiòtics sobre la infecció per rotavirus en un model de rates lactants

https://diposit.ub.edu/dspace/handle/2445/106937

2016

Efecte dels components bioactius del cacau sobre la microbiota i el sistema immunitari intestinal de rata

https://diposit.ub.edu/dspace/handle/2445/96076

2015

Efecte d’una dieta enriquida amb cacau sobre la resposta immunitària i anafilàctica en un model d’al·lèrgia alimentària en rata

https://diposit.ub.edu/dspace/handle/2445/66547

2015